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New York (CNN Business)The various Covid-19 vaccines currently being distributed around the globe have the potential to end the worst pandemic in a century. They also will mean hundreds of billions dollars in sales for the pharmaceutical companies that make them.

PROVIDENCE, R.I. (AP) — The road to a COVID-19 shot often leads through a maze of scheduling systems: Some vaccine seekers spend days or weeks trying to book online appointments. Those who get a coveted slot can still be stymied by pages of forms or websites that slow to a crawl and crash.

Public health efforts almost eradicated Guinea worm disease in humans. However, a few years ago, researchers realized the disease had become prevalent in dogs – and could cross back over into human populations. To prevent the disease from roaring back, researchers are now developing computational models they can use to drive down disease occurrence in man’s best friend.

George Dantzig introduced the world to the power of optimization, creating trillions of dollars of value and saving countless years of life across the globe. In this laudation, John Birge describes the fascinating life and incredible accomplishments of a scholar whose footprints led the way to almost everything the global economy produces.